High-Grade Transformation of Adenoid Cystic Carcinoma Delineated with a Fibrous Rim: A Case Report

High-Grade Transformation of Adenoid Cystic Carcinoma Delineated with a Fibrous Rim: A Case Report

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Background: High-grade transformation or dedifferentiation in carcinoma is progression click here of a low-grade malignant neoplasm to a high-grade carcinoma or poorly differentiated adenocarcinoma.This is rarely observed in adenoid cystic carcinoma of the salivary glands.Case Report: A 39 year-old woman presented with a painless mass at the left submandibulary region that had been growing slowly for 5 years.

Submandibulary mass resection revealed a mass with peripheral adenoid cystic carcinoma and a central high-grade tumor delineated with a fibrous rim, raising the possibility of a hybrid opi the color that keeps on giving or composite carcinoma, requiring differential diagnosis depending upon morphology and immunohistochemistry findings.The final histopathological diagnosis was high-grade transformation of adenoid cystic carcinoma.After surgical therapy, the patient was irradiated to the neck and submandibulary region.

No sign of tumor recurrence has been evident for 36 months.Conclusion: This present case seems to be another rare case with high-grade transformation of adenoid cystic carcinoma and the fibrous rim may be a histopathological feature of such cases, which should be kept in mind.